Sample result

Human insulin's gene

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The search

Query: INS · 333 lettersATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG
From: NCBI RefSeq NM_000207.3, bases 60 to 392
Search: DNA → Patent DNA · Automatic (BLAST)
Set: Public patent sequences: Patent DNA, snapshot 2026-11-05-c456f6bdba29
Ran: 2026-11-12
Found: 3,194 sequences, 1,584 publications, 1,066 families

Each query returns up to 5,000 sequences and 5 alignments per sequence. BLAST may miss matches. These results do not establish patentability.

Patents

1,584 publications in 1,066 families match these filters.

US 11192930-B22021-12-07

Ultra-long acting insulin-Fc fusion protein and methods of use

Askton Bioscences Corporation

Query Match 17.1%Identity 87.8%

Best alignment

Query 71 to 152, hit 56 to 137. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| ||||||||||||||  |||||||||||||||| || || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCGACCTGGTGGAAGCTCTGTATCTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTACAC 152
          | || || ||||||||||||||
Hit   116 GCGAGCGGGGCTTCTTCTACAC 137

72 of 82 identical, no gaps.

US 11198719-B22021-12-14

Ultra-long acting insulin-Fc fusion protein and methods of use

Akston Biosciences Corporation

Query Match 17.1%Identity 87.8%Family of 2
Best alignment and family
Query 71 to 152, hit 56 to 137. Positions start at 1 and include both ends.
```
Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| ||||||||||||||  |||||||||||||||| || || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCGACCTGGTGGAAGCTCTGTATCTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTACAC 152
          | || || ||||||||||||||
Hit   116 GCGAGCGGGGCTTCTTCTACAC 137
```
72 of 82 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- US 11198719-B22021-12-14
- US 11814418-B22023-11-14

US 12240881-B22025-03-04

Ultra-long acting insulin-Fc fusion protein and methods of use

DECHRA LIMITED

Query Match 17.1%Identity 87.8%

Best alignment

Query 71 to 152, hit 56 to 137. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| ||||||||||||||  |||||||||||||||| || || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCGACCTGGTGGAAGCTCTGTATCTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTACAC 152
          | || || ||||||||||||||
Hit   116 GCGAGCGGGGCTTCTTCTACAC 137

72 of 82 identical, no gaps.

US 6476290-A2002-11-05

Transgenic tilapia comprising a humanized insulin gene

Dalhousie University

Query Match 16.7%Identity 90.1%

Best alignment

Query 70 to 162, hit 345 to 437. Positions start at 1 and include both ends.

Query  70 GCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGC 129
          ||||| ||| | || ||||||||||| || ||||||||||| || || ||||| || ||
Hit   345 GCCTTCGTGCAGCAGCACCTGTGCGGATCCCACCTGGTGGAGGCCCTGTACCTGGTCTGT 404

Query 130 GGGGAACGAGGCTTCTTCTACACACCCAAGACC 162
          |||||  |||||||||||||||| |||||||||
Hit   405 GGGGAGAGAGGCTTCTTCTACACCCCCAAGACC 437

78 of 93 identical, no gaps.

KR 1020000058003-A2000-10-02

Vector for Curing Diabetes Mellitus Containing Gene of Single-chain Insulin Analog

Query Match 16.4%Identity 90.3%

Best alignment

Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180

65 of 72 identical, no gaps.

JP 2002320490-A2002-11-05

Single-stranded insulin analog for treating diabetes and vector containing gene thereof

HYUN CHUL LEE

Query Match 16.4%Identity 90.3%

Best alignment

Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180

65 of 72 identical, no gaps.

US 6630348-A2003-10-07

Single-chain insulin analog and a polynucleotide sequence encoding the analog

Query Match 16.4%Identity 90.3%

Best alignment

Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180

65 of 72 identical, no gaps.

WO 2004031372-A2004-04-15

Immortalized human hepatocyte cell line secreting modified insulin with glucose sensitivity

Naoya Kobayashi,Noriaki Tanaka,Teru Okitsu,Ji-Won Yoon,Hee-Sook Jun, Seungjin Shin

Query Match 16.4%Identity 90.3%
Best alignment
Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.
```
Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180
```
65 of 72 identical, no gaps.

US 7312077-A2007-12-25

Insulin-secreting immortalized liver cell line modified by glucose sensitivity

Query Match 16.4%Identity 90.3%

Best alignment

Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180

65 of 72 identical, no gaps.

EP 2009095-A12008-12-31

Method of generating glucose-responsive cells

Innovalor AG (CH)

Query Match 16.4%Identity 90.3%Family of 2
Best alignment and family
Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.
```
Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180
```
65 of 72 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- EP 2009095-A12008-12-31
- WO 2009000555-A12008-12-31

US 7919080-B22011-04-05

Immortalized hepatocyte cell line secreting modified insulin with glucose sensitivity

Query Match 16.4%Identity 90.3%

Best alignment

Query 262 to 333, hit 109 to 180. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || |||||||| || |||||||||||||| ||||||||||| ||||||||||||||||||
Hit   109 AAACGTGGCATCGTTGAACAATGCTGTACTAGCATCTGCTCTCTCTACCAGCTGGAGAAC 168

Query 322 TACTGCAACTAG 333
          || || ||||||
Hit   169 TATTGTAACTAG 180

65 of 72 identical, no gaps.

US 4617384-A1986-10-14

Adaptor molecules for DNA and their application to synthesis of gene-derived products

Cornell Research Foundation, Inc.

Query Match 15.9%Identity 97.2%
Best alignment
Query 268 to 330, hit 1 to 63. Positions start at 1 and include both ends.
```
Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||| || ||||| ||||||||||||||||||||||| |||||||||||||||
Hit     1 GGCATTGTGGAGCAGTGCTGCACCAGCATCTGCTCCCTCTACCAACTGGAGAACTACTGC 60

Query 328 AAC 330
          |||
Hit    61 AAC 63
```
59 of 63 identical, no gaps.

US 11596699-B22023-03-07

RNA encoding an antibody

CureVac SE

Query Match 15.8%Identity 90.5%

Best alignment

Query 73 to 152, hit 1 to 80. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||||| |||||||| ||||| || ||||| |||||||| || |||||
Hit     1 TTCGTCAACCAACACCTCTGCGGCTCCCACCTCGTCGAAGCCCTCTACCTCGTCTGCGGC 60

Query 133 GAACGAGGCTTCTTCTACAC 152
          ||||| ||||||||||||||
Hit    61 GAACGCGGCTTCTTCTACAC 80

69 of 80 identical, no gaps.

US 12195511-B22025-01-14

Ultra-long acting insulin-Fc fusion protein

Akston Biosciences Corporation

Query Match 15.6%Identity 85.4%

Best alignment

Query 71 to 152, hit 56 to 137. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| ||||||||||||||  ||||||||||||||||    || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCGACCTGGTGGAAGCTCTGGCTCTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTACAC 152
          | || || ||||||||||||||
Hit   116 GCGAGCGGGGCTTCTTCTACAC 137

70 of 82 identical, no gaps.

EP 2061895-A12009-05-27

Transgenic mammals that produce exogenous proteins in milk

STERRENBELD BIOTECHNOLOGIE NOR

Query Match 15.3%Identity 100.0%
Best alignment
Query 283 to 333, hit 76 to 26. Positions start at 1 and include both ends.
```
Query 283 TGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 333
          |||||||||||||||||||||||||||||||||||||||||||||||||||
Hit    76 TGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 26
```
51 of 51 identical, no gaps.

US 6001604-A1999-12-14

Refolding of proinsulins without addition of reducing agents

Query Match 15.2%Identity 84.5%

Best alignment

Query 73 to 165, hit 193 to 285. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| ||||| |||||||| || || |||||||| ||||| || ||||| || || ||
Hit   193 TTTGTCAACCAGCACCTGTGTGGTTCTCACCTGGTTGAAGCACTGTACCTGGTATGTGGC 252

Query 133 GAACGAGGCTTCTTCTACACACCCAAGACCCGC 165
          ||||| || ||||||||||| || || ||||||
Hit   253 GAACGTGGTTTCTTCTACACTCCTAAAACCCGC 285

76 of 93 identical, no gaps.

US 11352407-B22022-06-07

Ultra-long acting insulin-Fc fusion proteins

Akston Biosciences Corporation

Query Match 15.0%Identity 85.7%

Best alignment

Query 71 to 150, hit 56 to 135. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| |||||||||||||| |||||||||||||||||  | || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAAGCTCTGGAACTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTAC 150
          | || || ||||||  ||||
Hit   116 GCGAGCGGGGCTTCCACTAC 135

68 of 80 identical, no gaps.

US 11555058-B22023-01-17

Cells engineered to express ultra-long acting insulin-Fc fusion proteins

Akston Biosciences Corporation

Query Match 15.0%Identity 85.7%

Best alignment

Query 71 to 150, hit 56 to 135. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| |||||||||||||| |||||||||||||||||  | || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAAGCTCTGGAACTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTAC 150
          | || || ||||||  ||||
Hit   116 GCGAGCGGGGCTTCCACTAC 135

68 of 80 identical, no gaps.

JP 2023507376-A2023-02-22

ULTRA-LONG ACTING INSULIN-FC FUSION PROTEINS AND METHODS OF USE

AKSTON BIOSCIENCES CORPORATION

Query Match 15.0%Identity 85.7%

Best alignment

Query 71 to 150, hit 56 to 135. Positions start at 1 and include both ends.

Query  71 CCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCG 130
          |||| |||||||| |||||||||||||| |||||||||||||||||  | || |||||||
Hit    56 CCTTCGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAAGCTCTGGAACTCGTGTGCG 115

Query 131 GGGAACGAGGCTTCTTCTAC 150
          | || || ||||||  ||||
Hit   116 GCGAGCGGGGCTTCCACTAC 135

68 of 80 identical, no gaps.

JP 2018537963-A2018-12-27

EVOLVED CAS9 PROTEINS FOR GENE EDITING

President and Fellows of Harvard College

Query Match 14.9%Identity 98.0%Family of 3
Best alignment and family
Query 118 to 168, hit 1 to 51. Positions start at 1 and include both ends.
```
Query 118 TACCTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGG 168
          ||||||||||||||||||||||||| |||||||||||||||||||||||||
Hit     1 TACCTAGTGTGCGGGGAACGAGGCTBCTTCTACACACCCAAGACCCGCCGG 51
```
50 of 51 identical, no gaps.
Family of 3
Grouped by a shared priority claim, US 62/279346.
- JP 2018537963-A2018-12-27
- US 12043852-B22024-07-23
- JP 2024125281-A2024-09-18
US 10676734-B22020-06-09

Compositions and methods for detecting nucleic acid regions

LIFE TECHNOLOGIES CORPORATION

Query Match 14.9%Identity 98.0%Family of 2
Best alignment and family
Query 118 to 168, hit 1 to 51. Positions start at 1 and include both ends.
```
Query 118 TACCTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGG 168
          ||||||||||||||||||||||||| |||||||||||||||||||||||||
Hit     1 TACCTAGTGTGCGGGGAACGAGGCTBCTTCTACACACCCAAGACCCGCCGG 51
```
50 of 51 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- US 10676734-B22020-06-09
- US 12116571-B22024-10-15

KR 1019920700456-A1992-02-28

METHOD OF PREPARING FUSION PROTEINS

Query Match 14.7%Identity 83.3%

Best alignment

Query 248 to 331, hit 109 to 192. Positions start at 1 and include both ends.

Query 248 AGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCT 307
          |||| || |||||||||||||| || || |||||||| ||||| || ||||| ||  | |
Hit   109 AGGGTTCTCTGCAGAAGCGTGGTATCGTTGAACAATGTTGTACTAGTATCTGTTCTTTGT 168

Query 308 ACCAGCTGGAGAACTACTGCAACT 331
          |||||||||| |||||||| ||||
Hit   169 ACCAGCTGGAAAACTACTGTAACT 192

70 of 84 identical, no gaps.

US 5856159-A1999-01-05

Production of galactosyltransferase

Query Match 14.7%Identity 87.2%

Best alignment

Query 1 to 77, hit 1 to 77. Positions start at 1 and include both ends.

Query  1 ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGG-GACCTGA 59
         |||||||| |||||||||||||||||||||||||| |||||||||||||||| | ||
Hit    1 ATGGCCCTCTGGATGCGCCTCCTGCCCCTGCTGGCCCTGCTGGCCCTCTGGGCGCCCGCG 60

Query 60 CCCAGCCGCAGCCTTTGT 77
         |||| ||| |||||| ||
Hit   61 CCCACCCG-AGCCTTCGT 77

68 of 78 identical, 2 gaps.

US 10046013-B22018-08-14

Engineered bacteria for oral delivery of glucoregulatory proteins

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Query Match 14.6%Identity 84.0%

Best alignment

Query 72 to 152, hit 14 to 94. Positions start at 1 and include both ends.

Query  72 CTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGG 131
          ||| || ||||| ||||||||||| ||  ||||||| |||||||| ||||| || |||||
Hit    14 CTTCGTTAACCAGCACCTGTGCGGTTCTGACCTGGTTGAAGCTCTGTACCTGGTTTGCGG 73

Query 132 GGAACGAGGCTTCTTCTACAC 152
           ||||| || |||||||||||
Hit    74 TGAACGTGGTTTCTTCTACAC 94

68 of 81 identical, no gaps.

WO 0177324-A12001-10-18

Dna immunization vectors

AdProTech Limited (GB)

Query Match 14.1%Identity 96.2%
Best alignment
Query 1 to 52, hit 1 to 52. Positions start at 1 and include both ends.
```
Query  1 ATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGG 52
         |||||||| |||||||||||||||||||||||||| ||||||||||||||||
Hit    1 ATGGCCCTCTGGATGCGCCTCCTGCCCCTGCTGGCCCTGCTGGCCCTCTGGG 52
```
50 of 52 identical, no gaps.
KR 1020240013773-A2024-01-30

METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES

ImCyse SA

Query Match 14.1%Identity 100.0%Family of 2
Best alignment and family
Query 224 to 270, hit 17 to 63. Positions start at 1 and include both ends.
```
Query 224 GCAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGC 270
          |||||||||||||||||||||||||||||||||||||||||||||||
Hit    17 GCAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGC 63
```
47 of 47 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- KR 1020240013773-A2024-01-30
- JP 2024520030-A2024-05-21
WO 2007020256-A12007-02-22

Method for making mature insulin polypeptides

Novo Nordisk A/S (DK)

Query Match 14.0%Identity 86.4%Family of 4
Best alignment and family
Query 73 to 161, hit 17 to 105. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit    17 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 76

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||| |||| ||||||||||| || |||||
Hit    77 GAAAGAGGTTTCTTCTACACTCCTAAGAC 105
```
72 of 89 identical, no gaps.
Family of 4
Grouped by the same title and applicant. No priority claim is on record.
- WO 2007020256-A12007-02-22
- WO 2014195452-A12014-12-11
- US 9056921-B22015-06-16
- JP 2016521701-A2016-07-25
JP 2009504169-A2009-02-05

Method for making maturated insulin polypeptides

Novo Nordisk A/S,Asser Sloth Andersen

Query Match 14.0%Identity 80.9%Family of 2
Best alignment and family
Query 73 to 161, hit 17 to 105. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit    17 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 76

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||| |||| ||||||||||| || |||||
Hit    77 GAAAGAGGTTTCTTCTACACTCCTAAGAC 105
```
72 of 89 identical, no gaps.
Family of 2
Grouped by a shared priority claim, EP 05107513.3.
- JP 2009504169-A2009-02-05
- JP 2013208119-A2013-10-10
WO 2010002283-A22010-01-07

New insulin analogues of prolonged activity

Instytut Biotechnologii I Antybiotykow (PL)

Query Match 14.0%Identity 85.3%Family of 2
Best alignment and family
Query 73 to 161, hit 4558 to 4646. Positions start at 1 and include both ends.
```
Query   73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
           ||||| ||||| |||||||| || || |||||||| ||||| || ||||| || || ||
Hit   4558 TTTGTCAACCAGCACCTGTGTGGTTCTCACCTGGTTGAAGCACTGTACCTGGTATGTGGC 4617

Query  133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
           ||||| || ||||||||||| || || ||
Hit   4618 GAACGTGGTTTCTTCTACACTCCTAAAAC 4646
```
72 of 89 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- WO 2010002283-A22010-01-07
- JP 2011526886-A2011-10-20

EP 2296692-A22011-03-23

ISOFORM-SPECIFIC INSULIN ANALOGUES

UNIV CASE WESTERN RESERVE

Query Match 14.0%Identity 81.8%

Best alignment

Query 73 to 158, hit 1 to 88. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||| ||||| ||||||   ||||| || ||||| |||||||| || |||||
Hit     1 TTCGTCAACCAGCACCTCTGCGGCAGCCACCTCGTCGAAGCACTCTACCTCGTCTGCGGA 60

Query 133 GAACGAGGCTTCTTCTACAC--ACCCAA 158
          |||||||| |||||||||||  ||||||
Hit    61 GAACGAGGATTCTTCTACACAGACCCAA 88

72 of 88 identical, 2 gaps.

JP 2011521621-A2011-07-28

ISOFORM-SPECIFIC INSULIN ANALOGUES

Case Western Reserve University

Query Match 14.0%Identity 81.8%

Best alignment

Query 73 to 158, hit 1 to 88. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||| ||||| ||||||   ||||| || ||||| |||||||| || |||||
Hit     1 TTCGTCAACCAGCACCTCTGCGGCAGCCACCTCGTCGAAGCACTCTACCTCGTCTGCGGA 60

Query 133 GAACGAGGCTTCTTCTACAC--ACCCAA 158
          |||||||| |||||||||||  ||||||
Hit    61 GAACGAGGATTCTTCTACACAGACCCAA 88

72 of 88 identical, 2 gaps.

EP 2371853-A22011-10-05

Insulin derivatives or its pharmaceutically acceptable salt, pharmaceutical composition, use of insulin derivative or its pharmaceutically acceptable salt and method of treatment

INST BIOTECHNOLOGII I ANTYBIOTYKOW

Query Match 14.0%Identity 85.3%
Best alignment
Query 73 to 161, hit 4558 to 4646. Positions start at 1 and include both ends.
```
Query   73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
           ||||| ||||| |||||||| || || |||||||| ||||| || ||||| || || ||
Hit   4558 TTTGTCAACCAGCACCTGTGTGGTTCTCACCTGGTTGAAGCACTGTACCTGGTATGTGGC 4617

Query  133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
           ||||| || ||||||||||| || || ||
Hit   4618 GAACGTGGTTTCTTCTACACTCCTAAAAC 4646
```
72 of 89 identical, no gaps.

US 8618048-B22013-12-31

Insulin analogues of prolonged activity

Instytut Biotechnologii I Antybiotykow

Query Match 14.0%Identity 85.3%

Best alignment

Query 73 to 161, hit 4558 to 4646. Positions start at 1 and include both ends.

Query   73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
           ||||| ||||| |||||||| || || |||||||| ||||| || ||||| || || ||
Hit   4558 TTTGTCAACCAGCACCTGTGTGGTTCTCACCTGGTTGAAGCACTGTACCTGGTATGTGGC 4617

Query  133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
           ||||| || ||||||||||| || || ||
Hit   4618 GAACGTGGTTTCTTCTACACTCCTAAAAC 4646

72 of 89 identical, no gaps.

EP 3405484-A12018-11-28

A METHOD FOR PRODUCING INSULIN AND INSULIN DERIVATIVES, AND HYBRID PEPTIDE USED IN THIS METHOD

INST BIOTECHNOLOGII I ANTYBIOTYKOW

Query Match 14.0%Identity 84.5%

Best alignment

Query 73 to 161, hit 1138 to 1226. Positions start at 1 and include both ends.

Query   73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
           ||||| ||||| |||||||| || || |||||||| ||||| || ||||| || || ||
Hit   1138 TTTGTCAACCAGCACCTGTGTGGTTCTCACCTGGTTGAAGCACTGTACCTGGTATGTGGC 1197

Query  133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
           ||||| || ||||||||||| || || ||
Hit   1198 GAACGTGGTTTCTTCTACACTCCTAAAAC 1226

72 of 89 identical, no gaps.

EP 3807306-A22021-04-21

LEADER SEQUENCE FOR HIGHER EXPRESSION OF RECOMBINANT PROTEINS

UNICHEM LAB LTD

Query Match 13.8%Identity 87.3%

Best alignment

Query 262 to 332, hit 214 to 284. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || ||||||||||||||||| ||||| ||||||||||||  ||| || |||||||| |||
Hit   214 AAACGTGGCATTGTGGAACAGTGCTGCACCAGCATCTGCAGCCTGTATCAGCTGGAAAAC 273

Query 322 TACTGCAACTA 332
          || ||||| ||
Hit   274 TATTGCAATTA 284

61 of 71 identical, no gaps.

JP 2021532730-A2021-12-02

LEADER SEQUENCE FOR HIGHER EXPRESSION OF RECOMBINANT PROTEINS

Unichem Laboratories Limited

Query Match 13.8%Identity 87.3%

Best alignment

Query 262 to 332, hit 214 to 284. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || ||||||||||||||||| ||||| ||||||||||||  ||| || |||||||| |||
Hit   214 AAACGTGGCATTGTGGAACAGTGCTGCACCAGCATCTGCAGCCTGTATCAGCTGGAAAAC 273

Query 322 TACTGCAACTA 332
          || ||||| ||
Hit   274 TATTGCAATTA 284

61 of 71 identical, no gaps.

EP 0347781-A21989-12-27

Mini-proinsulin, its oroduction and use.

HOECHST AKTIENGESELLSCHAFT

Query Match 13.5%Identity 84.0%

Best alignment

Query 257 to 331, hit 96 to 22. Positions start at 1 and include both ends.

Query 257 TGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGG 316
          ||||||||||||| || || |||||||| ||||| || ||||| ||  | ||||||||||
Hit    96 TGCAGAAGCGTGGTATCGTTGAACAATGTTGTACTAGTATCTGTTCTTTGTACCAGCTGG 37

Query 317 AGAACTACTGCAACT 331
          | |||||||| ||||
Hit    36 AAAACTACTGTAACT 22

63 of 75 identical, no gaps.

US 10508308-B22019-12-17

Assays for diagnosing type 1 diabetes

L2 Disgnostics, LLC

Query Match 13.5%Identity 70.0%

Best alignment

Query 8 to 187, hit 100 to 279. Positions start at 1 and include both ends.

Query   8 TGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCG 67
          ||||||||||  |  ||    || ||||| || |||   | ||||||  |||   || ||
Hit   100 TGTGGATGCGTTTTTTGTTTTTGTTGGCGTTGTTGGTTTTTTGGGGATTTGATTTAGTCG 159

Query  68 CAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGT 127
           ||  ||||||||  || |  ||||||| | | |  ||||||||| | | ||  ||||||
Hit   160 TAGTTTTTGTGAATTAATATTTGTGCGGTTTATATTTGGTGGAAGTTTTTTATTTAGTGT 219

Query 128 GCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGG 187
          ||||||||||||| || || || | |   ||||  || ||||||| ||||||  || |||
Hit   220 GCGGGGAACGAGGTTTTTTTTATATATTTAAGATTCGTCGGGAGGTAGAGGATTTGTAGG 279

126 of 180 identical, no gaps.

EP 0214826-A21987-03-18

Insulin analogues and method of preparing the same.

NOVO-NORDISK A/S

Query Match 13.4%Identity 92.6%

Best alignment

Query 73 to 159, hit 6 to 92. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit     6 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 65

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit    66 GAAAGAGGTTTCTTCTACACTCCTAAG 92

70 of 87 identical, no gaps.

WO 8902463-A11989-03-23

SYNTHETIC YEAST LEADER PEPTIDES

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 202 to 288. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   202 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 261

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   262 GAAAGAGGTTTCTTCTACACTCCTAAG 288

70 of 87 identical, no gaps.

WO 9010075-A11990-09-07

YEAST PROCESSING SYSTEM COMPRISING A NEGATIVELY CHARGED AMINO ACID ADJACENT TO THE PROCESSING SITE

Query Match 13.4%Identity 88.6%

Best alignment

Query 73 to 159, hit 236 to 322. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   236 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 295

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   296 GAAAGAGGTTTCTTCTACACTCCTAAG 322

70 of 87 identical, no gaps.

WO 9211378-A11992-07-09

A METHOD OF CONSTRUCTING SYNTHETIC LEADER SEQUENCES

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 277 to 363. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   277 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 336

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   337 GAAAGAGGTTTCTTCTACACTCCTAAG 363

70 of 87 identical, no gaps.

KR 1019960700049-A1996-01-08

A DNA CONTRUCT ENCODING THE YAP3 SIGNAL PEPTIDE

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 294 to 380. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   294 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 353

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   354 GAAAGAGGTTTCTTCTACACTCCTAAG 380

70 of 87 identical, no gaps.

US 5639642-A1997-06-17

Synthetic leader peptide sequences

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 190 to 276. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   190 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 249

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   250 GAAAGAGGTTTCTTCTACACTCCTAAG 276

70 of 87 identical, no gaps.

US 5726038-A1998-03-10

DNA construct encoding the YAP3 signal peptide

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 294 to 380. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   294 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 353

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   354 GAAAGAGGTTTCTTCTACACTCCTAAG 380

70 of 87 identical, no gaps.

US 5750497-A1998-05-12

Acylated insulin

Query Match 13.4%Identity 84.8%

Best alignment

Query 73 to 159, hit 335 to 421. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   335 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 394

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   395 GAAAGAGGTTTCTTCTACACTCCTAAG 421

70 of 87 identical, no gaps.

US 5795746-A1998-08-18

Synthetic leader peptide sequences

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 190 to 276. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   190 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 249

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   250 GAAAGAGGTTTCTTCTACACTCCTAAG 276

70 of 87 identical, no gaps.

JP 2000060556-A2000-02-29

Acylated insulin

NOVO NORDISK A/S

Query Match 13.4%Identity 84.8%Family of 2

Best alignment and family

Query 73 to 159, hit 335 to 421. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   335 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 394

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   395 GAAAGAGGTTTCTTCTACACTCCTAAG 421

70 of 87 identical, no gaps.

Family of 2

Grouped by a shared priority claim, DK 1044/93.

JP 2000060556-A2000-02-29
JP 2002308899-A2002-10-23

JP 2001507574-A2001-06-12

N-terminally extended proteins expressed in yeast

NOVO NORDISK AS

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 325 to 411. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   325 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 384

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   385 GAAAGAGGTTTCTTCTACACTCCTAAG 411

70 of 87 identical, no gaps.

JP 2001527387-A2001-12-25

Synthetic leader peptide sequences

NOVO NORDISK AS

Query Match 13.4%Identity 86.4%

Best alignment

Query 73 to 159, hit 328 to 414. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| ||||||| || ||| |||| |||||| | ||| | || |||||
Hit   328 TTCGTTAACCAACACTTGTGCGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGCGGT 387

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   388 GAAAGAGGTTTCTTCTACACTCCTAAG 414

70 of 87 identical, no gaps.

Human insulin's gene

The search

Patents

Family of 2

Family of 2

Family of 3

Family of 2

Family of 2

Family of 4

Family of 2

Family of 2

Family of 2