Sample result

Human insulin's gene

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The search

Query: INS · 333 lettersATGGCCCTGTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGCAGCCTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGGGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG
From: NCBI RefSeq NM_000207.3, bases 60 to 392
Search: DNA → Patent DNA · Automatic (BLAST)
Set: Public patent sequences: Patent DNA, snapshot 2026-11-05-c456f6bdba29
Ran: 2026-11-12
Found: 3,194 sequences, 1,584 publications, 1,066 families

Each query returns up to 5,000 sequences and 5 alignments per sequence. BLAST may miss matches. These results do not establish patentability.

Patents

1,584 publications in 1,066 families match these filters.

WO 2004009629-A12004-01-29

Monomeric insulin

Genemedix PLC (GB)

Query Match 12.2%Identity 85.7%

Best alignment

Query 268 to 330, hit 91 to 153. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || ||||| |||||||||||||||  |||||||||| | |||||  |||| |||||||||
Hit    91 GGTATTGTCGAACAATGCTGTACCTCCATCTGCTCCTTGTACCAATTGGAAAACTACTGC 150

Query 328 AAC 330
          |||
Hit   151 AAC 153

54 of 63 identical, no gaps.

JP 2006508695-A2006-03-16

A Novel Monomeric Insulin, a Pharmaceutical Composition comprising said monomeric insulin, and Preparation thereof

GeneMedix plc,Shanghai C A S Shenglongda Biotech(Group) Company, Youshang ZHANG,Jinguo DING,Dafu CUI,Jaihao SHI

Query Match 12.2%Identity 85.7%
Best alignment
Query 268 to 330, hit 91 to 153. Positions start at 1 and include both ends.
```
Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || ||||| |||||||||||||||  |||||||||| | |||||  |||| |||||||||
Hit    91 GGTATTGTCGAACAATGCTGTACCTCCATCTGCTCCTTGTACCAATTGGAAAACTACTGC 150

Query 328 AAC 330
          |||
Hit   151 AAC 153
```
54 of 63 identical, no gaps.
US 10238741-B22019-03-26

Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Query Match 12.2%Identity 87.9%
Best alignment
Query 90 to 147, hit 252 to 309. Positions start at 1 and include both ends.
```
Query  90 GTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGGGAACGAGGCTTCTTC 147
          ||||||||| ||||||||||||||||| ||||| |||||||| ||   ||||||||||
Hit   252 GTGCGGCTCTCACCTGGTGGAAGCTCTGTACCTCGTGTGCGGCGAGGAAGGCTTCTTC 309
```
51 of 58 identical, no gaps.

WO 9011299-A11990-10-04

NOVEL INSULIN COMPOUNDS

Query Match 11.9%Identity 78.2%

Best alignment

Query 73 to 159, hit 161 to 75. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| |||| || || ||| |||| |||||| | ||| | || || ||
Hit   161 TTCGTTAACCAACACTTGTGTGGTTCTCACTTGGTTGAAGCTTTGTACTTGGTTTGTGGT 102

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit   101 GAAAGAGGTTTCTTCTACACTCCAAAG 75

68 of 87 identical, no gaps.

WO 9907735-A21999-02-18

RECOMBINANT EXPRESSION OF INSULIN C-PEPTIDE

DZIEGLEWSKA HANNA EVA (GB)

Query Match 11.9%Identity 83.6%

Best alignment

Query 165 to 261, hit 1062 to 1158. Positions start at 1 and include both ends.

Query  165 CCGGGAGGCAGAGGACCTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGG 224
           ||| || || ||||||||||| || || ||||| || |||||||| ||||| ||||||||
Hit   1062 CCGCGAAGCTGAGGACCTGCAAGTTGGTCAGGTTGAACTGGGCGGTGGCCCGGGTGCAGG 1121

Query  225 CAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAG 261
           |    |||||||  ||||  | || || || || |||
Hit   1122 CTCTTTGCAGCCGCTGGCTTTAGAAGGTTCTCTTCAG 1158

74 of 97 identical, no gaps.

JP 2001512745-A2001-08-28

Recombinant expression of insulin C-peptide

CREATIVE PEPTIDES SWEDEN AB

Query Match 11.9%Identity 83.6%Family of 2
Best alignment and family
Query 165 to 261, hit 1062 to 1158. Positions start at 1 and include both ends.
```
Query  165 CCGGGAGGCAGAGGACCTGCAGGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGG 224
           ||| || || ||||||||||| || || ||||| || |||||||| ||||| ||||||||
Hit   1062 CCGCGAAGCTGAGGACCTGCAAGTTGGTCAGGTTGAACTGGGCGGTGGCCCGGGTGCAGG 1121

Query  225 CAGCCTGCAGCCCTTGGCCCTGGAGGGGTCCCTGCAG 261
           |    |||||||  ||||  | || || || || |||
Hit   1122 CTCTTTGCAGCCGCTGGCTTTAGAAGGTTCTCTTCAG 1158
```
74 of 97 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- JP 2001512745-A2001-08-28
- US 6558924-A2003-05-06

EP 2700654-A12014-02-26

HUMAN INSULIN AND ANALOG CONJUGATE THEREOF

CHONGQING FAGEN BIOMEDICAL INC

Query Match 11.9%Identity 78.2%

Best alignment

Query 73 to 159, hit 25 to 111. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| ||||||||  |||| || || ||| |||| |||||| | ||| | || || ||
Hit    25 TTTGTTAACCAACATTTGTGTGGTTCCCACTTGGTTGAAGCTTTGTACTTGGTTTGTGGT 84

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          ||| |||| ||||||||||| || |||
Hit    85 GAAAGAGGTTTCTTCTACACTCCAAAG 111

68 of 87 identical, no gaps.

KR 1020240094203-A2024-06-25

Method for producing recombinant protein using PDI derived from Trichoderma sp. strain

CJ CheilJedang Corporation

Query Match 11.9%Identity 78.2%Family of 2
Best alignment and family
Query 73 to 159, hit 10 to 96. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| || |||||| | || || || ||| | |||||||| || || |||||||||||
Hit    10 TTTGTTAATCAACACTTATGTGGTTCCCACTTAGTGGAAGCCCTTTATCTAGTGTGCGGA 69

Query 133 GAACGAGGCTTCTTCTACACACCCAAG 159
          || || ||||| ||||| || || |||
Hit    70 GAGCGTGGCTTTTTCTATACCCCTAAG 96
```
68 of 87 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- KR 1020240094203-A2024-06-25
- JP 2025528374-A2025-08-28
JP 1990100685-A1990-04-12

POLYPEPTIDE SECRETION EXPRESSION VECTOR, MICROORGANISM TRANSFORMED WITH SAME VECTOR AND PRODUCTION OF POLYPEPTIDE BY SAME MICROORGANISM

RES DEV CORP OF JAPAN, KATO CHIAKI, HORIKOSHI KOKI

Query Match 11.7%Identity 77.5%
Best alignment
Query 73 to 161, hit 787 to 875. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || || || ||||| || || || ||||| || |||||  | ||||| || |||||
Hit   787 TTCGTCAATCAGCACCTTTGTGGTTCTCACCTCGTTGAAGCCTTGTACCTTGTTTGCGGT 846

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||||| || ||||||||||| || |||||
Hit   847 GAACGTGGTTTCTTCTACACTCCTAAGAC 875
```
69 of 89 identical, no gaps.

WO 9703089-A21997-01-30

INSULIN

UNIV LEICESTER (GB)

Query Match 11.7%Identity 77.5%

Best alignment

Query 73 to 161, hit 1 to 89. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| |||| || || ||| |||| |||||  | ||| | || || ||
Hit     1 TTCGTTAACCAACACTTGTGTGGTTCTCACTTGGTTGAAGCCTTGTACTTGGTTTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||| |||| ||||||||||| || |||||
Hit    61 GAAAGAGGTTTCTTCTACACTCCAAAGAC 89

69 of 89 identical, no gaps.

US 6337194-A2002-01-08

Method for the preparation of insulin by cleavage of a fusion protein and fusion proteins containing insulin A and B chains

Query Match 11.7%Identity 77.5%

Best alignment

Query 73 to 161, hit 1 to 89. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||||||| |||| || || ||| |||| |||||  | ||| | || || ||
Hit     1 TTCGTTAACCAACACTTGTGTGGTTCTCACTTGGTTGAAGCCTTGTACTTGGTTTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||| |||| ||||||||||| || |||||
Hit    61 GAAAGAGGTTTCTTCTACACTCCAAAGAC 89

69 of 89 identical, no gaps.

JP 2024523476-A2024-06-28

Novel mRNA vaccine for autoimmunity

The Trustees of Columbia University in the City of New York

Query Match 11.1%Identity 87.5%
Best alignment
Query 91 to 147, hit 1 to 57. Positions start at 1 and include both ends.
```
Query  91 TGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGGGAACGAGGCTTCTTC 147
          || || || ||||||||||| ||||||||||| ||||| ||||| || |||||||||
Hit     1 TGTGGTTCCCACCTGGTGGAGGCTCTCTACCTGGTGTGTGGGGAGCGTGGCTTCTTC 57
```
49 of 57 identical, no gaps.

KR 1020160101702-A2016-08-25

A long acting insulin conjugate or analog thereof

HANMI PHARM. CO., LTD

Query Match 11.0%Identity 93.8%

Best alignment

Query 73 to 161, hit 4 to 92. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| || ||||| ||||| ||    ||||| ||||||||  | ||  |||| |||||
Hit     4 TTTGTAAATCAACATCTGTGTGGGAGTCACCTTGTGGAAGCATTATATTTAGTCTGCGGT 63

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||||| || ||||||||||| || || ||
Hit    64 GAACGTGGATTCTTCTACACTCCTAAAAC 92

68 of 89 identical, no gaps.

JP 2018508504-A2018-03-29

Long-Acting Insulin or Insulin analogue conjugate

HANMI PHARM CO LTD

Query Match 11.0%Identity 93.8%Family of 2
Best alignment and family
Query 73 to 161, hit 4 to 92. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| || ||||| ||||| ||    ||||| ||||||||  | ||  |||| |||||
Hit     4 TTTGTAAATCAACATCTGTGTGGGAGTCACCTTGTGGAAGCATTATATTTAGTCTGCGGT 63

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||||| || ||||||||||| || || ||
Hit    64 GAACGTGGATTCTTCTACACTCCTAAAAC 92
```
68 of 89 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- JP 2018508504-A2018-03-29
- US 10894089-B22021-01-19

EP 0182383-A11986-05-28

Process for the preparation of oligo- and polydeoxyribonucleotides

VEPEX Contractor Ltd.

Query Match 10.8%Identity 92.6%

Best alignment

Query 268 to 333, hit 10 to 75. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||| || ||||| || |||||    |||||||| || |||||||| |||||||||||
Hit    10 GGCATCGTTGAACAGTGTTGTACTTCTATCTGCTCTCTTTACCAGCTTGAGAACTACTGT 69

Query 328 AACTAG 333
          ||||||
Hit    70 AACTAG 75

54 of 66 identical, no gaps.

JP 1981154999-A1981-11-30

SYNTHESIS OF SELECTIVE AGED PROTEIN OR POLYPEPTIDE IN BACTERIA MATRIX

UNIV HARVARD

Query Match 10.5%Identity 82.1%

Best alignment

Query 9 to 75, hit 18 to 83. Positions start at 1 and include both ends.

Query  9 GTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGC 68
         |||||||||| |||||||||||||||| ||||| | ||||||||  ||  | || ||| |
Hit   18 GTGGATGCGCTTCCTGCCCCTGCTGGCCCTGCTCGTCCTCTGGGAGCCCAAGCCTGCC-C 76

Query 69 AGCCTTT 75
         || ||||
Hit   77 AGGCTTT 83

55 of 67 identical, 1 gap.

US 4338397-A1982-07-06

Mature protein synthesis

President and Fellows of Harvard College

Query Match 10.5%Identity 82.1%

Best alignment

Query 9 to 75, hit 17 to 82. Positions start at 1 and include both ends.

Query  9 GTGGATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGC 68
         |||||||||| |||||||||||||||| ||||| | ||||||||  ||  | || ||| |
Hit   17 GTGGATGCGCTTCCTGCCCCTGCTGGCCCTGCTCGTCCTCTGGGAGCCCAAGCCTGCC-C 75

Query 69 AGCCTTT 75
         || ||||
Hit   76 AGGCTTT 82

55 of 67 identical, 1 gap.

KR 1020170106373-A2017-09-20

INSULIN ANALOGUES WITH SELECTIVE SIGNALING PROPERTIES AND REDUCED MITOGENICITY

CASE WESTERN RESERVE UNIVERSITY

Query Match 10.5%Identity 81.5%Family of 4
Best alignment and family
Query 268 to 332, hit 97 to 161. Positions start at 1 and include both ends.
```
Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || |||||||||||   |||||||||  | |||||  ||||||||||||||
Hit    97 GGAATCGTTGAGCAATGCTGTACTTCCATCTGCTCATTGTACCAATTGGAGAACTACTGC 156

Query 328 AACTA 332
          |||||
Hit   157 AACTA 161
```
53 of 65 identical, no gaps.
Family of 4
Grouped by the same title and applicant. No priority claim is on record.
- KR 1020170106373-A2017-09-20
- JP 2018505874-A2018-03-01
- US 10472406-B22019-11-12
- US 10703792-B22020-07-07

EP 3223844-A12017-10-04

HALOGENATED INSULIN ANALOGUES OF ENHANCED BIOLOGICAL POTENCY

UNIV CASE WESTERN RESERVE

Query Match 10.5%Identity 81.5%

Best alignment

Query 268 to 332, hit 97 to 161. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || |||||||||||   |||||||||  | |||||  ||||||||||||||
Hit    97 GGAATCGTTGAGCAATGCTGTACTTCCATCTGCTCATTGTACCAATTGGAGAACTACTGC 156

Query 328 AACTA 332
          |||||
Hit   157 AACTA 161

53 of 65 identical, no gaps.

EP 3247720-A12017-11-29

INSULIN ANALOGUES WITH SELECTIVE SIGNALING PROPERTIES AND REDUCED MITOGENICITY

UNIV CASE WESTERN RESERVE

Query Match 10.5%Identity 81.5%

Best alignment

Query 268 to 332, hit 97 to 161. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || |||||||||||   |||||||||  | |||||  ||||||||||||||
Hit    97 GGAATCGTTGAGCAATGCTGTACTTCCATCTGCTCATTGTACCAATTGGAGAACTACTGC 156

Query 328 AACTA 332
          |||||
Hit   157 AACTA 161

53 of 65 identical, no gaps.

JP 2017537065-A2017-12-14

HALOGENATED INSULIN ANALOGUES OF ENHANCED BIOLOGICAL POTENCY

CASE WESTERN RESERVE UNIVERSITY

Query Match 10.5%Identity 81.5%

Best alignment

Query 268 to 332, hit 97 to 161. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || |||||||||||   |||||||||  | |||||  ||||||||||||||
Hit    97 GGAATCGTTGAGCAATGCTGTACTTCCATCTGCTCATTGTACCAATTGGAGAACTACTGC 156

Query 328 AACTA 332
          |||||
Hit   157 AACTA 161

53 of 65 identical, no gaps.

US 10822386-B22020-11-03

Insulin analogues with enhanced stability and reduced mitogenicity

Case Western Reserve University

Query Match 10.5%Identity 81.5%

Best alignment

Query 268 to 332, hit 97 to 161. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || |||||||||||   |||||||||  | |||||  ||||||||||||||
Hit    97 GGAATCGTTGAGCAATGCTGTACTTCCATCTGCTCATTGTACCAATTGGAGAACTACTGC 156

Query 328 AACTA 332
          |||||
Hit   157 AACTA 161

53 of 65 identical, no gaps.

WO 2009087081-A22009-07-16

Novel insulin derivatives having an extremely delayed time-action profile

Sanofi-Aventis Deutschland GmbH (DE)

Query Match 10.4%Identity 97.3%Family of 4
Best alignment and family
Query 291 to 327, hit 56 to 20. Positions start at 1 and include both ends.
```
Query 291 CAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||||||||||| |||||||||||||||||
Hit    56 CAGCATCTGCTCCCTCTACGAGCTGGAGAACTACTGC 20
```
36 of 37 identical, no gaps.
Family of 4
Grouped by the same title and applicant. No priority claim is on record.
- WO 2009087081-A22009-07-16
- WO 2009087082-A22009-07-16
- KR 1020100111682-A2010-10-15
- KR 1020100111683-A2010-10-15
JP 2011509088-A2011-03-24

Novel insulin derivatives having an extremely delayed time-action profile

Sanofi-Aventis Deutschland GmbH

Query Match 10.4%Identity 97.3%
Best alignment
Query 291 to 327, hit 56 to 20. Positions start at 1 and include both ends.
```
Query 291 CAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||||||||||| |||||||||||||||||
Hit    56 CAGCATCTGCTCCCTCTACGAGCTGGAGAACTACTGC 20
```
36 of 37 identical, no gaps.
JP 2011509269-A2011-03-24

Novel insulin derivatives having an extremely delayed time-action profile

Sanofi-Aventis Deutschland GmbH

Query Match 10.4%Identity 97.3%
Best alignment
Query 291 to 327, hit 56 to 20. Positions start at 1 and include both ends.
```
Query 291 CAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||||||||||| |||||||||||||||||
Hit    56 CAGCATCTGCTCCCTCTACGAGCTGGAGAACTACTGC 20
```
36 of 37 identical, no gaps.
US 8603970-B22013-12-10

Insulin derivatives having an extremely delayed time-action profile

Sanofi-Aventis Deutschland GmbH

Query Match 10.4%Identity 97.3%
Best alignment
Query 291 to 327, hit 56 to 20. Positions start at 1 and include both ends.
```
Query 291 CAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||||||||||| |||||||||||||||||
Hit    56 CAGCATCTGCTCCCTCTACGAGCTGGAGAACTACTGC 20
```
36 of 37 identical, no gaps.
US 8633156-B22014-01-21

Insulin derivative having an extremely delayed time-action profile

Sanofi-Aventis Deutschland GMBH

Query Match 10.4%Identity 97.3%
Best alignment
Query 291 to 327, hit 56 to 20. Positions start at 1 and include both ends.
```
Query 291 CAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          ||||||||||||||||||| |||||||||||||||||
Hit    56 CAGCATCTGCTCCCTCTACGAGCTGGAGAACTACTGC 20
```
36 of 37 identical, no gaps.
KR 1020140057589-A2014-05-13

N-GLYCOSYLATED INSULIN ANALOGUES

MERCK SHARP & DOHME CORP

Query Match 10.2%Identity 78.5%Family of 2
Best alignment and family
Query 73 to 161, hit 256 to 344. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| || |||||| |||| || || ||| |||| || ||| | ||| | || || ||
Hit   256 TTTGTTAATCAACACTTGTGTGGTTCCCACTTGGTTGAGGCTTTGTACTTGGTTTGTGGT 315

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||  |||| |||||||||||   ||||||
Hit   316 GAGAGAGGTTTCTTCTACACTAACAAGAC 344
```
67 of 89 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- KR 1020140057589-A2014-05-13
- EP 2744510-A12014-06-25

JP 2014525922-A2014-10-02

GLYCOSYLATED INSULIN ANALOGUES

Merck Sharp and Dohme Corp

Query Match 10.2%Identity 78.5%

Best alignment

Query 73 to 161, hit 256 to 344. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          ||||| || |||||| |||| || || ||| |||| || ||| | ||| | || || ||
Hit   256 TTTGTTAATCAACACTTGTGTGGTTCCCACTTGGTTGAGGCTTTGTACTTGGTTTGTGGT 315

Query 133 GAACGAGGCTTCTTCTACACACCCAAGAC 161
          ||  |||| |||||||||||   ||||||
Hit   316 GAGAGAGGTTTCTTCTACACTAACAAGAC 344

67 of 89 identical, no gaps.

KR 1020160088013-A2016-07-25

Method for Preparing Recombinant Protein Using EDA as a Fusion Expression Partner

Korea University Research and Business Foundation

Query Match 10.1%Identity 78.9%
Best alignment
Query 262 to 332, hit 109 to 179. Positions start at 1 and include both ends.
```
Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          || ||||| ||||| ||||||||||||||    ||||| ||  | || || || ||||||
Hit   109 AAACGTGGTATTGTTGAACAATGCTGTACATCAATCTGTTCATTGTATCAACTTGAGAAC 168

Query 322 TACTGCAACTA 332
          ||||| |||||
Hit   169 TACTGTAACTA 179
```
56 of 71 identical, no gaps.

US 11261228-B22022-03-01

Insulin derivatives with a terminal LPXT motif

Query Match 9.8%Identity 80.0%

Best alignment

Query 268 to 332, hit 109 to 173. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || || || || || || |||||   |||||| ||||| |||||| |||||||||||||
Hit   109 GGTATCGTTGAGCAGTGTTGTACTTCCATCTGTTCCCTGTACCAGTTGGAGAACTACTGT 168

Query 328 AACTA 332
          |||||
Hit   169 AACTA 173

52 of 65 identical, no gaps.

JP 2010504742-A2010-02-18

Method for making maturated insulin polypeptides

Novo Nordisk A/S

Query Match 9.6%Identity 77.8%

Best alignment

Query 262 to 333, hit 126 to 197. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          ||| | || ||||| ||||||||||||||    || |||||| |  | ||  |||| |||
Hit   126 AAGAGAGGTATTGTCGAACAATGCTGTACATCGATATGCTCCTTGGAACAATTGGAAAAC 185

Query 322 TACTGCAACTAG 333
          ||||||||||||
Hit   186 TACTGCAACTAG 197

56 of 72 identical, no gaps.

US 8518668-B22013-08-27

Method for making maturated insulin polypeptides in a fungal cell

Novo Nordisk A/S

Query Match 9.6%Identity 77.8%

Best alignment

Query 262 to 333, hit 126 to 197. Positions start at 1 and include both ends.

Query 262 AAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAAC 321
          ||| | || ||||| ||||||||||||||    || |||||| |  | ||  |||| |||
Hit   126 AAGAGAGGTATTGTCGAACAATGCTGTACATCGATATGCTCCTTGGAACAATTGGAAAAC 185

Query 322 TACTGCAACTAG 333
          ||||||||||||
Hit   186 TACTGCAACTAG 197

56 of 72 identical, no gaps.

WO 2011147894-A12011-12-01

CHIMERIC MHC CLASS II PROTEINPEPTIDE

FORSCHUNGSVERBUND BERLIN EV

Query Match 9.2%Identity 86.7%
Best alignment
Query 94 to 141, hit 84 to 131. Positions start at 1 and include both ends.
```
Query  94 GGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGGGAACGAGGC 141
          || || ||||||||||| ||||||||||| ||||| ||||| || |||
Hit    84 GGTTCCCACCTGGTGGAGGCTCTCTACCTGGTGTGTGGGGAGCGTGGC 131
```
41 of 48 identical, no gaps.
KR 1020170029512-A2017-03-15

REDUCING INTRON RETENTION

University of Southampton

Query Match 9.0%Identity 100.0%Family of 8
Best alignment and family
Query 261 to 290, hit 1 to 30. Positions start at 1 and include both ends.
```
Query 261 GAAGCGTGGCATTGTGGAACAATGCTGTAC 290
          ||||||||||||||||||||||||||||||
Hit     1 GAAGCGTGGCATTGTGGAACAATGCTGTAC 30
```
30 of 30 identical, no gaps.
Family of 8
Grouped by a shared priority claim, GB 1410693.4.
- KR 1020170029512-A2017-03-15
- JP 2017519766-A2017-07-20
- US 9714422-B22017-07-25
- US 9745577-B22017-08-29
- US 10538764-B22020-01-21
- US 11390869-B22022-07-19
- JP 2023011885-A2023-01-24
- US 11891605-B22024-02-06

EP 3204410-A22017-08-16

BIPHASIC SINGLE-CHAIN INSULIN ANALOGUES

UNIV CASE WESTERN RESERVE

Query Match 9.0%Identity 75.0%

Best alignment

Query 73 to 152, hit 1 to 80. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||| ||| |||| || || ||| |||| || ||| | ||| | || || ||
Hit     1 TTCGTTAACCAGCACTTGTGTGGTTCCCACTTGGTTGAGGCTTTGTACTTGGTTTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACAC 152
          ||  |||| |||||||||||
Hit    61 GAGAGAGGTTTCTTCTACAC 80

60 of 80 identical, no gaps.

JP 2017536337-A2017-12-07

BIPHASIC SINGLE-CHAIN INSULIN ANALOGUES

CASE WESTERN RESERVE UNIVERSITY

Query Match 9.0%Identity 75.0%Family of 3
Best alignment and family
Query 73 to 152, hit 1 to 80. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || ||||| ||| |||| || || ||| |||| || ||| | ||| | || || ||
Hit     1 TTCGTTAACCAGCACTTGTGTGGTTCCCACTTGGTTGAGGCTTTGTACTTGGTTTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACAC 152
          ||  |||| |||||||||||
Hit    61 GAGAGAGGTTTCTTCTACAC 80
```
60 of 80 identical, no gaps.
Family of 3
Grouped by the same title and applicant. No priority claim is on record.
- JP 2017536337-A2017-12-07
- US 10392429-B22019-08-27
- US 11142560-B22021-10-12
US 12281301-B22025-04-22

Sequencing-based proteomics

THE BROAD INSTITUTE, INC. and MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Query Match 9.0%Identity 100.0%
Best alignment
Query 285 to 314, hit 30 to 1. Positions start at 1 and include both ends.
```
Query 285 CTGTACCAGCATCTGCTCCCTCTACCAGCT 314
          ||||||||||||||||||||||||||||||
Hit    30 CTGTACCAGCATCTGCTCCCTCTACCAGCT 1
```
30 of 30 identical, no gaps.
US 4914026-A1990-04-03

Alpha factor leader sequence directed secretion of insulin

Chiron Corporation

Query Match 8.7%Identity 100.0%
Best alignment
Query 78 to 106, hit 29 to 1. Positions start at 1 and include both ends.
```
Query  78 GAACCAACACCTGTGCGGCTCACACCTGG 106
          |||||||||||||||||||||||||||||
Hit    29 GAACCAACACCTGTGCGGCTCACACCTGG 1
```
29 of 29 identical, no gaps.
JP 2005510533-A2005-04-21

Polynucleotide Therapy

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Query Match 8.7%Identity 89.7%Family of 3
Best alignment and family
Query 295 to 333, hit 25 to 63. Positions start at 1 and include both ends.
```
Query 295 ATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 333
          ||||| || || |||||||| ||||||||||||||||||
Hit    25 ATCTGTTCACTGTACCAGCTAGAGAACTACTGCAACTAG 63
```
35 of 39 identical, no gaps.
Family of 3
Grouped by a shared priority claim, US 60/332070.
- JP 2005510533-A2005-04-21
- US 7544669-A2009-06-09
- JP 2011219479-A2011-11-04
US 7030098-A2006-04-18

DNA vaccination for treatment of autoimmune disease

The Board of Trustees of the Leland Stanford Junior University

Query Match 8.7%Identity 89.7%Family of 2
Best alignment and family
Query 295 to 333, hit 25 to 63. Positions start at 1 and include both ends.
```
Query 295 ATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 333
          ||||| || || |||||||| ||||||||||||||||||
Hit    25 ATCTGTTCACTGTACCAGCTAGAGAACTACTGCAACTAG 63
```
35 of 39 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- US 7030098-A2006-04-18
- US 7704970-B22010-04-27
US 7579328-A2009-08-25

DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus

The Board of Trustees of the Leland Stanford Junior University

Query Match 8.7%Identity 89.7%Family of 2
Best alignment and family
Query 295 to 333, hit 25 to 63. Positions start at 1 and include both ends.
```
Query 295 ATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 333
          ||||| || || |||||||| ||||||||||||||||||
Hit    25 ATCTGTTCACTGTACCAGCTAGAGAACTACTGCAACTAG 63
```
35 of 39 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- US 7579328-A2009-08-25
- US 8748404-B22014-06-10
EP 2301552-A12011-03-30

Polynucleotide therapy

UNIV LELAND STANFORD JUNIOR

Query Match 8.7%Identity 89.7%Family of 3
Best alignment and family
Query 295 to 333, hit 25 to 63. Positions start at 1 and include both ends.
```
Query 295 ATCTGCTCCCTCTACCAGCTGGAGAACTACTGCAACTAG 333
          ||||| || || |||||||| ||||||||||||||||||
Hit    25 ATCTGTTCACTGTACCAGCTAGAGAACTACTGCAACTAG 63
```
35 of 39 identical, no gaps.
Family of 3
Grouped by the same title and applicant. No priority claim is on record.
- EP 2301552-A12011-03-30
- EP 2301553-A12011-03-30
- EP 2322185-A22011-05-18
KR 1020150096387-A2015-08-24

LONG-ACTING SINGLE-CHAIN INSULIN ANALOGUES

CASE WESTERN RESERVE UNIVERSITY

Query Match 8.6%Identity 75.0%Family of 4
Best alignment and family
Query 73 to 160, hit 1 to 87. Positions start at 1 and include both ends.
```
Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || || |||||| |||| || || ||| |||| || ||  | ||| | || || ||
Hit     1 TTCGTCAATCAACACTTGTGTGGTTCCCACTTGGTTGAGGCATTGTACTTGGTCTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACACACCCAAGA 160
          ||  |||| ||||||||||| ||| |||
Hit    61 GAGAGAGGATTCTTCTACAC-CCCTAGA 87
```
65 of 88 identical, 1 gap.
Family of 4
Grouped by the same title and applicant. No priority claim is on record.
- KR 1020150096387-A2015-08-24
- JP 2016506366-A2016-03-03
- US 9499600-B22016-11-22
- US 9975940-B22018-05-22

EP 2914620-A22015-09-09

LONG-ACTING SINGLE-CHAIN INSULIN ANALOGUES

UNIV CASE WESTERN RESERVE

Query Match 8.6%Identity 75.0%

Best alignment

Query 73 to 160, hit 1 to 87. Positions start at 1 and include both ends.

Query  73 TTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGGG 132
          || || || |||||| |||| || || ||| |||| || ||  | ||| | || || ||
Hit     1 TTCGTCAATCAACACTTGTGTGGTTCCCACTTGGTTGAGGCATTGTACTTGGTCTGTGGT 60

Query 133 GAACGAGGCTTCTTCTACACACCCAAGA 160
          ||  |||| ||||||||||| ||| |||
Hit    61 GAGAGAGGATTCTTCTACAC-CCCTAGA 87

65 of 88 identical, 1 gap.

EP 0163406-A11985-12-04

Novel polypeptide expression method

Canadian Patents and Development Limited Societe Canadienne des Brevets et d'Exploitation Limitee

Query Match 8.4%Identity 100.0%
Best alignment
Query 303 to 330, hit 1 to 28. Positions start at 1 and include both ends.
```
Query 303 CCTCTACCAGCTGGAGAACTACTGCAAC 330
          ||||||||||||||||||||||||||||
Hit     1 CCTCTACCAGCTGGAGAACTACTGCAAC 28
```
28 of 28 identical, no gaps.
US 6300093-A2001-10-09

Islet cell antigen 1851

ZymoGenetics, Inc. and University of Washington

Query Match 8.3%Identity 96.7%
Best alignment
Query 130 to 159, hit 30 to 1. Positions start at 1 and include both ends.
```
Query 130 GGGGAACGAGGCTTCTTCTACACACCCAAG 159
          |||||||| |||||||||||||||||||||
Hit    30 GGGGAACGTGGCTTCTTCTACACACCCAAG 1
```
29 of 30 identical, no gaps.
US 6627735-A2003-09-30

Islet cell antigen 1851

ZymoGenetics, Inc.

Query Match 8.3%Identity 96.7%
Best alignment
Query 130 to 159, hit 30 to 1. Positions start at 1 and include both ends.
```
Query 130 GGGGAACGAGGCTTCTTCTACACACCCAAG 159
          |||||||| |||||||||||||||||||||
Hit    30 GGGGAACGTGGCTTCTTCTACACACCCAAG 1
```
29 of 30 identical, no gaps.

EP 2406377-A22012-01-18

A POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCE AND METHODS THEREOF

BIGTEC PRIVATE LTD

Query Match 8.3%Identity 76.9%

Best alignment

Query 268 to 332, hit 352 to 416. Positions start at 1 and include both ends.

Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || ||||| |||||||| || ||    ||||| ||  | |||||  |||||||||||||
Hit   352 GGTATTGTTGAACAATGTTGCACTTCAATCTGTTCTTTGTACCAATTGGAGAACTACTGT 411

Query 328 AACTA 332
          |||||
Hit   412 AACTA 416

50 of 65 identical, no gaps.

US 8575322-B22013-11-05

Polynucleotide and polypeptide sequence and methods thereof

Bigtec Private Limited

Query Match 8.3%Identity 76.9%Family of 2
Best alignment and family
Query 268 to 332, hit 352 to 416. Positions start at 1 and include both ends.
```
Query 268 GGCATTGTGGAACAATGCTGTACCAGCATCTGCTCCCTCTACCAGCTGGAGAACTACTGC 327
          || ||||| |||||||| || ||    ||||| ||  | |||||  |||||||||||||
Hit   352 GGTATTGTTGAACAATGTTGCACTTCAATCTGTTCTTTGTACCAATTGGAGAACTACTGT 411

Query 328 AACTA 332
          |||||
Hit   412 AACTA 416
```
50 of 65 identical, no gaps.
Family of 2
Grouped by the same title and applicant. No priority claim is on record.
- US 8575322-B22013-11-05
- US 9238674-B22016-01-19

Human insulin's gene

The search

Patents

Family of 2

Family of 2

Family of 2

Family of 4

Family of 4

Family of 2

Family of 8

Family of 3

Family of 3

Family of 2

Family of 2

Family of 3

Family of 4

Family of 2